We have previously reported that cultures of C. albicans activated the amebocyte lysate clotting cascade of the Japanese horseshoe crab Tachypleus tridentatus. In order to isolate the active agent ...

Thrombolysis with tissue plasminogen activator (tPA) has been utilized as a treatment for acute ischemic stroke in select patients. However, the effects of tPA on the coagulation cascade and its ...

See Figure 1 for a depiction of normal hemostasis. The activation of the coagulation cascade yields thrombin that converts fibrinogen to fibrin; the stable fibrin clot being the final product of ...