Sister chromatids do not break apart during this tug-of-war because they are firmly attached to each other by the cohesin remaining at their centromeres. At the end of prometaphase, chromosomes ...

According to Dr. Gibcus, during the mitotic phase of cell division, four different loop-extruding machines are acting simultaneously along the chromosomes: two types of cohesin machines and two ...

2009). In collaboration with Bryan Tsou’s group in the Cell Biology Program at the Sloan Kettering Institute, we used similar approaches to show that Plk1 and the cohesin protease separase act ...

The separase cuts the cohesin rings, which hold the sister chromatids together. These then migrate to the opposite poles of the spindle apparatus. Disclaimer: AAAS and EurekAlert! are not ...

Cohesin acts as a marker that attracts HORMAD1 and is responsible for tying it onto the chromosome. To use this media elsewhere, the authors request a reference to the original work be included.