With its selection of kits (cAMP femto, cAMP dynamic and cAMP HiRange), Cisbio allows detection of a broad range of cyclic AMP concentrations. Classically, the GPCR signaling pathway is considered ...

Adenylyl cyclase creates multiple cyclic AMP molecules, which fan out and activate protein kinases (PKA, in this example). Protein kinases can enter the nucleus and affect transcription.

The brain on drugs Drugs elevate CREB activity in the nucleus accumbens by activating cyclic AMP pathway, causing protein kinase A to translocate to the nucleus and phosphorylate CREB. Target genes ...

The cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic ...

A novel strategy using lipid nanoparticles to reprogram liver immunity shows promise in generating antitumor responses ...

The research compares how two bacterial species—Escherichia coli and Mycobacterium tuberculosis—use a signaling molecule called cyclic AMP (cAMP) to control important cellular functions.