The ongoing exploration of EPAC and PKA pathways may lead to innovative therapeutic strategies that harness the power of these signaling mechanisms. Cyclic AMP (cAMP): A second messenger important ...

The signal transduction cascade begins when adenylyl ... Adenylyl cyclase creates multiple cyclic AMP molecules, which fan out and activate protein kinases (PKA, in this example).

A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...

Earl W. Sutherland Jr., former professor and chair of the Department of Pharmacology, led the discovery of cyclic AMP, a cellular signaling molecule responsible for many metabolic processes. He won ...

A new study led by Dr. Rodrigo Maillard at Georgetown University, “Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein through Structural Homology,” published in ...

A new study, "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein" published in Biochemistry, provides key insights into how bacterial cAMP receptor proteins (CRPs) ...