They mimic, manipulate and usurp cellular functions, but always with an interesting twist. γ-herpesvirus genomes encode an abundance of homologues of cellular factors, including cyclin and Bcl-2.

An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.

Interestingly, the protein can exert both positive and negative functions on these processes ... of Cdks by assembly and import of D-type cyclin–Cdks, the potential for cytoplasmic p27 to ...