(B) CDK1 and CDK2 bind to multiple cyclins (cyclin types A, B, D and E), whereas CDK4 and CDK6 only partner D-type cyclins. Thick lines represent the preferred pairing for each kinase. (C ...

Additional work focuses on the regulation of novel downstream substrates of the cyclin D1/CDK4 kinase and their role in mediating cyclin D1-dependent effects on tumor cell gene expression networks. A ...

Viruses are the masters of trickery. They mimic, manipulate and usurp cellular functions, but always with an interesting twist. γ-herpesvirus genomes encode an abundance of homologues of cellular ...