Sander, M. et al. Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy. Proc. Natl. Acad. Sci.USA 97, 13818–13823 ...

Patients with degenerative diseases that attack skeletal muscle tissues, such as Duchenne muscular dystrophy, may soon benefit from novel stem cell therapies. A study has demonstrated how new ...

DMD, a severe genetic disorder that causes muscle weakness and shortens lifespans ... how these proteins function differently in various tissues, we’re one step closer to designing treatments ...

domain of dystrophin and its role in stabilizing cellular membranes across various tissues. DMD, a severe genetic disorder that causes muscle weakness and shortens lifespans, arises from mutations ...

A new study has shed light on the complex interactions between dystrophin, a protein critical to muscle ... tissues, we're one step closer to designing treatments that target the root causes of DMD." ...

In 1986, researchers discovered the gene that, when defective or flawed, causes Duchenne muscular dystrophy ... These may include: Muscle biopsy. A small piece of muscle tissue is removed and ...

This damage is compounded by increased intracellular calcium levels, which impair mitochondrial function and activate calcium-dependent enzymes that degrade muscle tissue. Over time, this cascade ...