UCLA Health researchers say study findings uncover Huntington's disease mechanisms and pave new ways to develop treatments.

A new paper, published today in Science, identifies widespread differences between DNA sequences and their corresponding RNA transcripts in human cells, and demonstrates that these differences result ...

the MMR hMSH2–hMSH6 heterodimer provides an important DNA damage signal for colorectal, endometrial and ovarian cells, and mutations in either of these genes leads to ineffective mismatch repair ...

Intriguingly, these regions contain multiple genes involved in repairing DNA mismatches. However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in ...

Such preformed distortions of DNA substrates could be optimal in BER ... including nucleotide excision repair 20 and mismatch repair 21.