Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

One is that the DNA template somehow becomes defective during replication, and causes the polymerase to pause (Figures 3 and 4a). For example, a DNA base can be chemically modified or ...

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production.

Researchers at the University of Gothenburg have identified a small molecule, PZL-A, that restores function in the defective ...

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers have identified a molecule that helps ...

However, the behind-the-scenes process of analyzing forensic DNA is far more intricate, requiring careful interpretation of the data. Forensic DNA profiling uses polymerase chain reaction (PCR) to ...

and the intervening gaps are filled in by DNA polymerase. The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ...

When the mechanisms that replicate or repair mitochondrial DNA (mtDNA) fail, it can cause a wide range of syndromes for which ...

Because this process was extremely time consuming and required a great deal of DNA, new methods like polymerase chain reaction and amplified fragment length polymorphism have been employed.The ...

Causes: POLG-related diseases are caused by several hundred different mutations in the POLG gene. This gene encodes a protein in mitochondria, called DNA polymerase gamma (pol γ), which is needed to ...

Applied DNA Sciences, Inc. (NASDAQ:APDN) (Applied DNA), a leader in PCR-based DNA technologies, today announced that on April 7, 2025, it received a notification letter from the Listing Qualifications ...