Whether it is a microbe, a rose, or a dolphin, any form of life gets its building and operating instructions from the molecule of life, DNA. DNA comprises the genes and chromosomes that govern the ...
However, conditions for DNA replication are rarely ideal. For example, environmental toxins or drugs cause DNA damage and interfere with DNA replication. How does a cell circumvent such problems?
Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine ...
A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...
But now we can also use DNA sequencing technologies to monitor wildlife, and all that is needed is a tiny sample of their DNA. When an organism, say a fish, moves through the environment it’s ...
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