Indeed, for NF-κB and NFAT, the DNA-binding domain is comprised of two Ig-fold regions; the N-terminal Ig-motif is responsible for sequence-specific DNA binding and the linker region that ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type ... nuclease domain and revealing the structural changes that occur upon DNA binding, this ...