Figure 1: Three pathways for loading major histocompatibility complex (MHC) class II molecules with peptides in dendritic cells. The presence of empty class II molecules on the surface of ...

In summary, peripherally derived dendritic cells that infiltrate the CNS seem to be crucial for EAE development. Moreover, evidence is emerging that overproduction of particular cytokines by ...

Do allogeneic dendritic cells offer an advantage? Figure 3: Direct CD4 + T-cell allorecognition for provision of T-cell help for the generation of self-MHC restricted T-cell responses to tumor ...

Multiple sclerosis (MS) is considered to be a predominantly T-cell-mediated disease, and emerging evidence indicates that dendritic cells have a critical role in the initiation and progression of ...