HR repair mechanisms minimize this by avoiding crossing ... which consist of complex patterns of direct and inverted LCRs. Some clustering might result from the absence of dosage-sensitive genes ...

Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.

This redundancy in repair mechanisms can be exploited for targeted ... proteins coming in and working on the DNA, and that direct visualisation is a great advance,” says Boulton.