New structural information on the interaction of erythropoietin with its receptor suggests that the orientation of receptor dimers is critical to intracellular activation. The discovery of novel ...

"To understand the molecular and structural basis of the physiological and pathogenic activation of JAK2, we used single-molecule microscopy and erythropoietin receptor (EpoR) as a model system.

Higher EPO and HIF lead to the secretion of ERFE from ... mothers against decapentaplegic; TfR1/2, Transferrin receptor; TMPRSS6, transmembrane serine protease 6; TWSG1, twisted gastrulation ...