The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

focusing on its role in pathogenesis through alterations in the endoplasmic reticulum (ER). In addition to engulfing superfluous cellular material, macrophages also handle hazardous lipid cargo in ...

The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

Our research group studies the mechanisms of protein trafficking and quality control at the endoplasmic reticulum (ER) in mammalian cells. A major focus of research is on the COPII protein machinery ...

Neurobiologists identify key protein Esyt linking calcium signaling to neurodegenerative diseases in cell membrane contact sites.

A key factor in the pathology of MASH is the disruption of endoplasmic reticulum (ER) homeostasis. The ER stores calcium ions (Ca 2+) and plays a crucial role in regulating protein folding ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

BACKGROUND: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes ...

Nwd1 deletion disrupts sarco/endoplasmic reticulum calcium ATPase (SERCA2) activity, which leads to heightened endoplasmic reticulum stress, contributing to metabolic dysfunction-associated ...