Different enhancers are therefore separated from each other, even if they control the same gene, and switch it on in different parts of the body. A recent study from the University of Bonn and the ...

A comprehensive analysis has identified novel enhancers associated with neuronal development and disease.

Morphology-controlling genes frequently react to multiple separate enhancers, each of which controls the gene's expression in a distinct body part. Enhancers were formerly believed to be modular.

before moving down the DNA to the gene. Enhancers are regions of DNA that act as molecular switches for turning genes on or off. Understanding enhancer function is very important, since they ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory ...

Jack is a science writer based in the San Francisco Bay Area. He has a bachelor’s degree in biology from Caltech and a PhD in molecular biology from Princeton University. He also completed a master’s ...

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

On the other hand, the tiny roundworm Caenorhabditis elegans has nearly as many genes as we do—approximately 20,000—but far fewer body parts. Tissue-specific enhancers can work over long ...

Then the authors engineered these sequences into the zebrafish genome next to a gene that encodes a fluorescent protein. Fascinatingly, six out of ten human enhancers (including one for a gene ...