Each enzyme has an active site, which is where the reaction takes place. The lock and key model explains how enzymes work: The enzyme is like a "lock". The substrate (the molecule it reacts with ...

What was needed was a simple quantitative assay for this enzyme ... Figure 1: The known active site of carboxypeptidase A and a hypothetical model of the active site of ACE.

Enzymes have active sites which only match specific substrates. The diagram shows how this works. In this example, the enzyme splits one molecule into two smaller ones, but other enzymes join ...

Our team showed that when we prompt an AI model, called RFdiffusion, with the structure and amino acid sequence of an active site, it can generate the rest of the enzyme structure that would ...