Some epigenetic drugs designed to treat cancer have the potential to be used as broad-spectrum antivirals. HMT EZH2/1 inhibitors can prevent viral gene expression and reduce herpes simplex virus ...
The most common HDAC inhibitors include phenylbutyric acid, SAHA, depsipeptide, and valproic acid (Egger et al., 2004). Caution in using epigenetic therapy is necessary because epigenetic ...
The Luo laboratory is also interested in designing and synthesizing epigenetic inhibitors with the emphasis of the distinct modes of action in disease-relevant contexts. Researchers in the Luo Lab ...
Redox regulators and epigenetic inhibitors demonstrate the ability to modulate gene expression and cellular metabolism, ...
We envision that in the next 5 years more epigenetic aberrations in endometriosis will be documented, catalogued and delineated. More specifically, we may see the difference in epigenetic ...
In this article, published data in support of the notion that endometriosis is an epigenetic disease are reviewed. The desirable properties of histone deacetylase inhibitors as therapeutics for ...
kinase inhibitors and epigenetic inhibitors. The study showed that higher expression of ALDH3A2 was positively correlated with the cytarabine sensitivity value. The study used a combination of the ...
Small molecule inhibitors, antisense oligonucleotides, and CRISPR-based gene editing tools are among the strategies being ...
1) The epigenetic regulations in drug resistance. Our preliminary data revealed that epigenetic regulation is involved in the resistance to one chemotherapeutic, CDK4/6 inhibitor. We determine how an ...
In addition, research is focused on protein-RNA complexes mediating the piRNA pathway (with Julius Brennecke, IMBA-Austria), on identification and characterization of small molecule inhibitors ...