JAK2V617F is a constitutively active tyrosine kinase that activates signal transducer and activator ... Jak kinase responsible for EPO receptor (EPOR) signalling 30. Figure 2: Mechanism of ...

Drugs that stimulate the erythropoietin receptor (EpoR) can replenish red blood cells ... by leading antibody companies like AbCam and Cell Signaling Technologies as well as academic organizations ...

JAK2-EpoR dimerization is a common mechanism for ... ago when we cloned the JAK2 gene and showed its function in cytokine signaling. Our subsequent studies have focused on the pseudokinase domain ...