Because ERBB2 binds no known ligand, only ERBB3 is shown with ligand bound. This activation leads to phosphorylation of specific tyrosines in the tail region of the receptors, activation of ...

Each ERBB receptor has distinct locations and numbers of tyrosine phosphorylation sites on its C-terminal tails; there are twelve on ERBB1, six on ERBB2, and eleven on ERBB3 (Jones et al.