Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

What is TP53 and what role does it play in cancer? Medically reviewed by Marla Anderson, MD. The TP53 gene is a gene that is ...

e,f, Haploinsufficient tumor-suppressor genes do not need to lose both functional ... and the other functional allele may be retained. In some examples (f), a partially or completely nonfunctional ...