e,f, Haploinsufficient tumor-suppressor genes do not need to lose both functional ... and the other functional allele may be retained. In some examples (f), a partially or completely nonfunctional ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

Tumor immune evasion mechanisms could be reversed by activating intracellular antiviral immune responses. It has been reported that the use of DNA methyltransferase (DNMT) inhibitors combined with ...

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel ...

For example, Ras proteins function as molecular ... oncogenes and oncogenes that drive the cell cycle forward, tumor suppressor genes code for proteins that normally operate to restrict cellular ...

For example, in 2016, researchers reported a case where LINE-1 inserted itself into a tumor suppressor gene, initiating colorectal cancer. But it appears to be much more common for transposable ...

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a ...

The red sea urchin (Mesocentrotus franciscanus) is one of the earth's longest-living animals, reported to live more than 100 ...