Infiltration and extravasation are one of the most destructive complications to the neonate's fragile skin. This article reviews multiple aspects of infiltration and extravasation injury.

The measurement of the concentration of hydrogen ions, pH, is another important consideration when evaluating a medication's risk of infiltration or extravasation. A normal pH of blood is between ...

History of severe cutaneous reaction: avoid. Increased risk for seizures (w. intrathecal use). Ensure adequate hydration. Avoid extravasation (esp. in arterial or venous disease). Elderly.