To establish whether molecules other than scFv antibody fragments could be lipid-modified and inserted into cell membranes, we cloned the gene encoding human interleukin-2 (IL-2) into vector pLP2 ...

Although fewer antibody fragments have entered the clinic than full-length monoclonal antibodies, proof-of-concept studies for these therapeutics remain the main hurdle. Tufts Center for the Study ...

Design concept of a novel antibody fragment format "Fv-clasp." Fv-clasp is a simple fusion of the SARAH domain derived from human Mst1 protein to the Fv (green: heavy chain, cyan: light chain ...