在体外和体内实验中，PF-670462显著增强了肿瘤细胞对铁死亡的敏感性，并在肿瘤模型中显著促进CD8+ T细胞浸润。更关键的是，PF-670462与抗PD-1免疫治疗联用时，使小鼠生存期明显延长，且未出现明显毒副作用。

撰文丨王聪编辑丨王多鱼排版丨水成文铁死亡（Ferroptosis）是近年来发现的一种新型细胞死亡方式，其与多种病理生理过程密切相关，包括衰老、神经退行性病变、缺血再灌注损伤、病毒感染，尤其是癌症进展。然而，铁死亡的翻译后调控机制，目前仍不完全清楚。2025 年 3 月 19 日，中山大学崔隽教授团队，在 Nature 子刊 ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent reactive ...

In recent years, chemotherapy-induced cardiovascular disease has emerged as a significant cause of mortality among cancer ...

This means that it can be observed in all the cancer cells examined and in most cytotoxic agents." During ferroptosis, polyunsaturated fatty acids in cell membranes are damaged by oxygen radicals.

Hepatocellular carcinoma (HCC) represents about 90% of all cases of liver cancer and has a poor prognosis, with a 5-year survival rate of about 18%. Previous findings had shown that RNA ...

Researchers from Soochow University and affiliated organizations presented data from a study that aimed to investigate the role of cyclic GMP-AMP synthase (cGAS) in tumorigenesis and tumor progression ...

研究发现，sorcin 在胰腺癌组织中高表达，且与患者的生存情况和肿瘤分期密切相关。进一步研究揭示，sorcin 通过非钙结合功能抑制铁死亡（ferroptosis），具体机制为：sorcin 与 PAX5 在细胞质中相互作用，抑制 PAX5 的核转位，进而降低 FBXL12 蛋白表达，减少 ALDH1A1 的 ...

Nat Cancer. Feb 2. Riegman M, Sagie L, Galed C, Levin T, Steinberg N, Dixon SJ, Wiesner U, Brandbury MS, Niethammer P, Zaritsky A, Overholtzer M. (2020) Ferroptosis occurs through an osmotic mechanism ...