识别出了病理性细胞的主要来源后，研究人员分析了一种名为Runx2的转录因子，其在正常成纤维细胞转化为病理性细胞过程中扮演着关键角色。阻断小鼠机体中Runx2基因的功能就会阻断正常成纤维细胞的转化并能将肺部中纤维化组织的水平减少大约50%的比例，此外研 ...

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and ...

2025 年 2 月 5 日，国际顶尖学术期刊 Nature 上线了 篇论文，其中 7 篇来自华人学者（包括作为通讯作者和第一作者的论文）。 2 月 5 日，哥伦比亚大学欧文医学中心阙建文教授和加州大学圣地亚哥分校孙欣教授作为通讯作者，在 ...

Researchers have been trying for decades to stop the cells that damage the lung in people with pulmonary fibrosis. Now a team ...

Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and ...

Not all scars are created equal. That's the conclusion of a new study by Weizmann Institute of Science researchers: They ...

The excessive activation of fibroblasts results in abnormal tissue growth at sites of injury or inflammation and creates the perfect conditions for fibrosis to occur. Researchers in the Arthur lab ...

Specifically, the mechano-regulation of inflammation, extracellular matrix and fibroblast functional phenotype that results in a spectrum of tissue fibrosis outcomes. We utilize basic science and ...

The genetic disorder cystic fibrosis is unique because it can cause both breathing and digestive problems. Some 40,000 people in the U.S. currently have it, "though this is likely an ...