Metronidazole exerts antibacterial effects in an anaerobic environment against most obligate anaerobes. Once metronidazole enters the organism by passive diffusion and activated in the cytoplasm ...

Patients who sustain thermal injury may require adjustments of antibiotic dosing because of pharmacokinetic alterations and pathological changes that occur in this patient subset. In general ...

Decreased renal function does not change the single-dose pharmacokinetics for metronidazole. Subjects with ESRD had no significant change in pharmacokinetics, but had higher Cmax of metabolites ...