Discovering a new folate trapping ... potent MTHFD1/2 inhibitors, including lead candidate TH9619, enabled the researchers to show the dependency between tumor metabolism DNA damage response ...

Recently, low folate levels have been linked to poorer antidepressant response to selective serotonin reuptake inhibitors ... involve the 1-carbon cycle, a pathway essential to many ...

Methotrexate is thought to act via folate-pathway enzymes; however, studies seeking associations between patient responses to methotrexate and single nucleotide polymorphisms (SNPs) in folate ...

Its role is within the folate-mediated one-carbon metabolism (FOCM ... Transformylase/Inosine Monophosphate Cyclohydrolase) inhibitor, increased lifespan in worms at low doses.