Recently, low folate levels have been linked to poorer antidepressant response to selective serotonin reuptake inhibitors ... involve the 1-carbon cycle, a pathway essential to many ...

Discovering a new folate trapping ... potent MTHFD1/2 inhibitors, including lead candidate TH9619, enabled the researchers to show the dependency between tumor metabolism DNA damage response ...

Its role is within the folate-mediated one-carbon metabolism (FOCM ... Transformylase/Inosine Monophosphate Cyclohydrolase) inhibitor, increased lifespan in worms at low doses.