Fondaparinux's extended half-life of 17–21 hours complicates its use as a perioperative bridging therapy. The ideal time for discontinuation before surgery is an issue, particularly in surgeries ...

Fondaparinux is a synthetic pentasaccharide that produces irreversible, antithrombin-mediated inhibition of Factor Xa. It has high bioavailability following subcutaneous injection and has a ...