Transport into and out of the nucleus is fundamental for many aspects of cellular function. Cargo molecules are transported through nuclear pore complexes (NPCs). Small molecules can pass by ...

Each nuclear pore complex (NPC) consists of more than 1,000 individual protein subunits with a total molecular mass of approximately 120 million daltons—the equivalent of more than 6.5 million water ...

"Yeast nuclear pores have long been known to have a 'central ... The NPC plays a crucial role in cellular function, and its dysfunction has been linked to numerous diseases, including progressive ...

By tethering transcription factors -- and with them, hundreds of genes -- to nuclear pore proteins, genes are moved to the edge of the nucleus, stimulating stronger gene expression. "Because ...

New research has identified the factors involved in the delicate balancing act of assembling and adjusting the number of ...