A number of cell surface and nuclear receptors mediate their actions via dimerization. While this has been well established, the dimerization of G-protein coupled receptors (GPCRs) (that ...

The first is a novel family of enzymes called the G protein–coupled receptor kinases (GRKs) including the βadrenergic receptor kinase (βRK), and the second is a group of proteins called arrestins.

However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein–coupled receptors ... recognize GRKs or arrestins. Thus, receptors can initiate signals ...

Regulation of G protein-coupled receptor signaling by arrestins: development of arrestin antisense approaches to study arrestin function and receptor specificity. Laboratory of Dr. Jeffrey L. Benovic, ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...

G protein-coupled receptors (GPCRs) are important ... GPCR kinases (GRKs), and β-arrestins. GPCR-biased agonism has raised the potential of novel drug development to preferentially activate ...