Scientists used advanced cryo-EM imaging to reveal how glutamate activates brain receptors, paving the way for new ...

Researchers used advanced cryo-electron microscopy to capture atomic-level images of how glutamate, a key neurotransmitter, ...

After assembling more than a million images taken with cryoEM, the team found that glutamate molecules act like a key that ...

Alzheimer's disease is one of the world’s most prevalent brain disorders, being extremely difficult to treat. Alzheimer's ...

NMDA receptors, members of the excitatory ionotropic glutamate receptor family ... of GluN2A and GluN2B subunits in vivo. Its structure showed a distinct assembly and asymmetric architecture.

This occurs by the clamshell-like structure of the AMPA receptor closing around glutamate, an action that pulls open the channel below. Twomey’s previous research has shown that drugs such as ...