A large and diverse number of diseases are now recognized as `conformational ... the nascent chain at which the first asparagine-linked glycosylation event occurs. BiP binding seems to be directly ...

"It is involved in the pathogenesis of several diseases, including cancer and neuronal disorders." However, glycosylation has ...

We use Drosophila and mouse genetics and cell culture experiments to understand the contribution of glycosylation and deglycosylation to the regulation of animal development and pathophysiology of ...

Furthermore, declining levels of this modification associated with age and disease suggest that restoring it might offer a new therapeutic approach. Role of Mucin-Type O-Glycosylation The present ...