Chlorpheniramine is a selective antagonist of the H1 histaminergic receptor subtype and its effects in humans include somnolence. Chlorpheniramine affects sleep in rats, mainly by decreasing REM ...

investigated the potential of the histamine H1 blocker hydroxyzine to improve sleep in patients with cirrhosis and minimal hepatic encephalopathy. All 35 patients (mean age 56 years [range 36–69 ...