and together with the results of gene targeting in mice provide an explanation for the critical role of ERBB2/HER2 in human cancer. Misregulated activation of ERBB receptors has been widely ...

Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

the chromosomal location of the c-erbB2 gene, in six of eight human biliary tract cancers analyzed, but the gain of 17q in this series was not accompanied by c-erbB-2 amplification. In contrast ...