本研究揭示了HIV-1逆转录酶（RT）稳定性及二聚化对蛋白酶（PR）激活和Gag-Pol二聚化的影响，为HIV/AIDS治疗提供了新靶点。 本文 ...

Figure 1: Structural organization of Gag-Pol polyprotein in HIV-1. We speculated that the low catalytic activity of the native p6 pol-protease precursor that is observed preceding its maturation ...

The Salk Institute recently made a breakthrough on the former subject by determining the molecular structure of HIV Pol, a protein that plays a role in the virus’ replication. The team found ...

HIV-1 Tat has been the vanguard of Pol II transcription elongation control for more than two decades 3.Nevertheless, its mechanism of action has ceased to be recognized as a viral peculiarity only ...

Gag and Gag-Pol, which are necessary for assembling infectious particles and replication of HIV-1. The researchers demonstrated that this extended RNA fold not only promotes ribosome collisions ...

and 215 in the pol gene were cross-checked by using a wild-type control (clone of HIV-1 subtype C in pNL4-3 vector, provided by Dr. Vijay Chaudhary, Department of Biochemistry, Delhi University ...