强直性脊柱炎（AS）被称为 “不死的癌症”，而 HLA-B27 阳性者更被贴上 “高危标签”。数据显示，90% 的 AS 患者携带 HLA-B27 基因，但仅有 5-10% 的阳性者会发病 —— 这一矛盾揭示了单纯基因检测无法解释疾病全貌。传统西医治疗以非甾体抗炎药（NSAIDs）、生物制剂（如 TNF-α 抑制剂）为主，但部分患者面临耐药性、感染风险或经济负担。 李征的突破点：他发现 ...

HLA-B27 positivity is linked to higher odds of non-remission in patients with juvenile idiopathic arthritis at 18 years after ...

不过，别慌张，接下来我将详细分析这个问题，帮助大家正确理解HLA-B27阳性和强直性脊柱炎与寿命之间的关系。 强直性脊柱炎对寿命的影响 首先要 ...

Researchers have found in a new research that HLA-B27 genetic marker is linked to a higher risk of various arthropathies, ...

Learn about enteropathic arthritis, a common extra-intestinal symptom of Crohn’s disease that affects the joints.

Patients with juvenile idiopathic arthritis (JIA) who carried the HLA-B27 genetic marker tended to have worse long-term outcomes, including lower rates of drug-free remission, in a prospective ...

Approximately one quarter of patients with psoriatic arthritis (PsA) exhibited axial involvement (axial PsA). Enthesitis, inflammatory bowel disease, and HLA-B27 positivity were associated with an ...

We did a series of co-precipitation experiments with arthritis-predisposing and neutral DR alleles and looked for the association of HSP73. Co-precipitation of HSP73 with HLA-DR was observed in ...

HLA-B27 codes for a protein that is on the surface ... ankylosing spondylitis or another form of axial spondyloarthritis arthritis. So a patient has back pain, Dr. Dubreuil. Should they be ...

Blood tests to look for the HLA-B27 gene can also be used to help diagnose ... DISH and AS are different forms of arthritis that can negatively affect a person’s life. Pain and stiffness are ...