强友们，现在微信改版了，阅读之前先“关注”+“星标”吧~每天第一时间看到最新强直科普文章 强直性脊柱炎（AS），这个名字听起来像个冷冰冰 ...

HLA-B27 positivity is linked to higher odds of non-remission in patients with juvenile idiopathic arthritis at 18 years after ...

强直性脊柱炎（AS）被称为 “不死的癌症”，而 HLA-B27 阳性者更被贴上 “高危标签”。数据显示，90% 的 AS 患者携带 HLA-B27 基因，但仅有 5-10% 的阳性者会发病 —— 这一矛盾揭示了单纯基因检测无法解释疾病全貌。传统西医治疗以非甾体抗炎药（NSAIDs）、生物制剂（如 TNF-α 抑制剂）为主，但部分患者面临耐药性、感染风险或经济负担。 李征的突破点：他发现 ...

不过，别慌张，接下来我将详细分析这个问题，帮助大家正确理解HLA-B27阳性和强直性脊柱炎与寿命之间的关系。 强直性脊柱炎对寿命的影响 首先要 ...

Researchers have found in a new research that HLA-B27 genetic marker is linked to a higher risk of various arthropathies, ...

Balan et al. used data from the National Institutes of Diabetes and Digestive and Kidney Diseases Liver Transplant database to assess the relationship between degree of HLA mismatching at the A ...

The exact cause of the juvenile ankylosing spondylitis is unknown. The disease is strongly linked to a gene known as HLA-B27. Approximately 80-90% of children with JAS have the HLA-B27 gene.

Among 434 patients followed in the cohort, odds of still showing active disease or needing medication 18 years after joining the study were nearly tripled in HLA-B27 carriers (OR 2.6, 95% CI 1.5-4 ...

Enthesitis, inflammatory bowel disease, and HLA-B27 positivity were associated with an increased risk for axial PsA. Among patients with axial PsA, 42.4% showed isolated sacroiliac joint ...