Excess cortisol secretion caused by an overactive hypothalamic–pituitary–adrenal (HPA) axis is detrimental to immune function, metabolism and blood pressure, but knowledge of the effect of ...
as well as in the regulation of the HPA axis. In women with the polycystic ovary syndrome (PCOS), cortisol production rate is probably normal, although adrenal androgens can be overproduced in a ...
leading to both HPA axis dysregulation and declarative memory deficit. The resultant elevated cortisol levels, they suggest, could then result in further hippocampal damage.
Through a negative feedback mechanism, an increase in circulating cortisol results in the inhibition of this cycle and suppression of its activity. Suppression of the HPA axis affects a patient's ...