这篇研究聚焦人乳头瘤病毒（HPV）相关宫颈癌。发现视网膜母细胞瘤蛋白（pRB）不仅是 HPV E7 的降解靶点，还对 E7 蛋白稳定至关重要。pRB 缺失会降低 E7 水平，抑制癌细胞增殖，为 HPV 相关癌症研究提供新思路。

几乎所有宫颈癌患者都存在持续的高危型人乳头瘤病毒（HPV）感染，尤其是 HPV-16 和 / 或 HPV-18 感染，会显著增加患病风险。HPV 基因组中的 E6 和 E7 蛋白可抑制肿瘤抑制因子 p53 和 pRb，促使癌细胞增殖。传统的宫颈癌一线治疗方法包括手术、放疗和化疗，对早期 ...

The E6 and E7 proteins are implicated in the transformation ... 1-3 and adenocarcinoma in situ (AIS) associated with HPV 16 and 18. In the FUTURE I intention-to-treat group, which included women ...

Gen-Probe is currently developing the APTIMA HPV Assay, targeting E6/E7 mRNA from 14 carcinogenic HPV genotypes. A prototype of this assay was evaluated recently in 536 women with histological ...

宫颈脱落细胞中HPV16/18 E7蛋白检测试剂盒（荧光免疫 ... 组成。临床上用于HPV感染的初步筛查。 由滴管、比色卡、染色液（含乙酸、乙酸钠、磷钨酸 ...

The phase III, randomized, controlled Papilloma Trial Against Cancer in Young Adults (PATRICIA) showed that the HPV-16/18 vaccine has enhanced immunogenicity when aluminium hydroxide and ...