Protein structure ... between the enzyme and highly reactive intermediates in a process known as enzyme–intermediate complementarity. The new focus on the protein folding problem, which includes ...

In 1961 the structure of one protein, myoglobin, was known at 6 Å resolution and its 2 Å structure would soon be published. The structural determinations of hemoglobin and hen lysozyme were well ...

Understanding how exactly protein folding occurs remains a key challenge ... folded forms of the nascent protein that are absent or highly unstable in isolation, yet long-lived on the ribosome.

For those fuzzy on the details, here’s a progressive timeline that led to this monumental achievement. 1972: Anfinsen Presents the Protein-Folding Problem In science, it is often hard to pinpoint when ...

A paper describing the research, which used a combination of computer simulations and refolding experiments to describe the folding kinetics of a protein called phosphoglycerate kinase (PGK ...