“It was very nice to see that upon modification of the protocol, it's possible to model hematopoiesis in a system that's already recapitulating aspects of heart development. This is because the ...

As in natural embryonic development, the artificial mini-heart consists of three cup-shaped layers and comprises the anlagen of the heart, the precursors for the liver and lungs and the blood vessels.

The formation of blood cellular components or hematopoiesis is a complex process regulated by genetic and epigenetic mechanisms. To ensure continuous blood cell production is necessary to preserve ...

Clonal hematopoiesis develops when a single HSC ... scientists haven't known exactly how this mutated gene affects blood cell development, growth or function. The LJI team used mouse models ...

Clonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that ...

Progress in biomedical research toward the development of efficient new therapeutics requires the study of human physiology and pathology in vivo. However, rigorous human disease experimentation ...

In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...