Heme biosynthesis is a vital biochemical process that produces heme, an iron-containing compound essential for various biological functions, including oxygen transport and electron transfer.

Recent research has focused on understanding the complex systems involved in heme biosynthesis and the maturation of cytochrome c, particularly in bacteria and eukaryotes. This research is ...

I discovered a conserved function for the mitochondrial protein unfoldase ClpX as an activator of the initial enzyme in heme biosynthesis, ALA synthase. ClpX performs an unusually targeted, partial ...

Bitopertin is an investigational, clinical-stage, orally administered inhibitor of glycine transporter 1 (GlyT1) that is designed to modulate heme biosynthesis. GlyT1 is a membrane transporter ...

And further experiments showed that removing any of the other enzymes in the heme biosynthesis pathway did not affect microRNA levels. "This told us that ALAS1 has another job outside of helping ...

"We have genetic and biochemical molecular studies to show that this metabolic process is completely reversed in order to detoxify ammonium that is generated to support heme biosynthesis," Xu said.

While the genes and enzymes involved in natural product biosynthesis are often known, a comprehensive understanding of the associated enzymology is still lacking. This gap presents a significant ...

X-linked sideroblastic anemia (XLSA) is a rare genetic disorder caused by mutations in the ALAS2 gene, which plays a critical role in heme biosynthesis within red blood cells.

Bitopertin is an investigational, clinical-stage, orally administered inhibitor of glycine transporter 1 (GlyT1) that is designed to modulate heme biosynthesis. GlyT1 is a membrane transporter ...