Higher EPO and HIF lead to the secretion of ERFE from erythroid precursor cells, which attenuates the BMP6 signaling cascade via GDF15/TWSG1. In the absence of BMP6, TMPRSS6 binds to ALK2 ...
Akebia’s drug, which like Jesduvroq (daprodustat) is an oral HIF-PHI inhibitor ... for anaemia based on recombinant erythropoietin (EPO), and are thought to stimulate the production of ...
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