该研究发现，缺氧诱导因子-1α（HIF-1α）驱动了癌症的铜死亡抵抗，而 HIF-1α 抑制剂可使实体瘤细胞对铜死亡敏感，这也揭示了缺氧促进癌症发生的 ...

Background Mechanical stress on the heart is commonly considered the sole stimulus explaining the synthesis and release of circulating natriuretic peptides and their derivatives. While one of the most ...

With the final step in HIF pathway established, scientists began to explore ways to utilize it. Because the hypoxia response is present across all tissues and cell types, the HIF pathway drives ...