Results of a study show convergent genetic adaptation under hypoxia (lack of oxygen) between populations living at ...

Tumour hypoxia has been pursued as a cancer drug target for over 30 years, most notably using bioreductive (hypoxia-activated) prodrugs that target antineoplastic agents to low-oxygen tumour ...

Results of study led by investigators at the Vall d'Hebron Institute of Oncology (VHIO) show convergent genetic adaptation ...

de la Calle-Fabregat, C., et al. (2024) NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the ...

Resistant cancer cells exhibit traits like drug efflux, enhanced DNA repair, protein homeostasis, and an immunosuppressive microenvironment. NOTCH signaling influences these traits through ...

Chemically restoring intestinal gut hypoxia could deter fungal blooms. Sahana is a science journalist and an ... a weakened immune system and disrupted gastrointestinal tract—a situation that ...

Oxidative stress, particularly, in the heart, is critical in different conditions, including hypertension, heart failure, ...