Bookkeepers handle more than numbers. They support small and large businesses, manage tax deadlines, and watch for potential pitfalls. FAB 2025 ...

【导读】免疫检查点阻断（ICB）疗法通过靶向程序性细胞死亡配体1（PD-L1）/程序性细胞死亡蛋白1（PD-1）轴以及细胞毒性T淋巴细胞相关蛋白4（CTLA-4），已在多种癌症类型中展现出显著的临床效果。然而，目前只有少数患者能够从ICB疗法中获益，这表明免疫检查点的潜在机制尚未完全明确。2月6日，大连医科大学刘雪峰/詹启敏团 ...

三阴乳腺癌（TNBC）是难治性乳腺癌亚型，传统治疗选择有限，化疗易产生耐药性和副作用，免疫检查点阻断（ICB）疗法仅部分患者有效。然而，许多三阴性乳腺癌肿瘤会产生耐药性，相关的副作用通常需要替代疗法。 免疫疗法，特别是免疫检查点阻断 ...

【导读】将免疫检查点阻断疗法（ICB）与化疗相结合有望治疗三阴性乳腺癌（TNBC），但对其机理仍不完全清楚。在这项研究中，团队整合了已发表的和新的单细胞RNA测序（scRNA-seq）数据，研究了接受紫杉醇（PTX）、纳布-紫杉醇（Nab-PTX）以 ...

为解决免疫治疗中多数患者无响应的难题，韩国延世大学医学院的研究人员开展一碳代谢（1CM）在肿瘤免疫微环境作用的研究，发现 1CM 是增殖性中间耗竭 T 细胞（Texint）的代谢标志。该成果为免疫治疗提供新思路，值得科研人员一读。

A company led by GPs is set to lose its OOH contract for Shropshire, after the local ICB revealed plans to award it to a ...

Niranjan Chandra Debnath has joined Investment Corporation of Bangladesh as managing director through a notification issued ...

A new diagnostics hub is on track to open in May, according to an NHS body. The Leicester, Leicestershire and Rutland Integrated Care Board (LLR ICB) said the £24.6m facility would provide about ...

Dental patients in the East of England will have access to almost 70,000 new, urgent appointments, the government announced.