IFN from the STING pathway activates the IFN receptor, which is sequentially phosphorylated by the receptor-coupled JAK as well as downstream STAT, and the phosphorylated STAT dimer transfers to the ...

Activated macrophages engulf the microbiota and produce increased levels of interleukin-23 and interleukin-12, resulting in the polarization of Th1 cells and Th17 cells, which produce proinflammatory ...

To assess the feasibility of targeted sequencing, the JAK–STAT signaling pathway elicited by interferon-β (IFN-β) was used as a model. This pathway leads to specific transcriptional changes ...

we provide evidence that IFN-γ drives a positive feedback loop in PAPA syndrome, and we explore the possibility of interrupting this amplification loop by targeting the Janus kinase (JAK)-signal ...

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JAK/STAT, and T-bet. In PD-1/PD-L1 immune checkpoint inhibitor cancer treatment, IFN-γ is a prognostic marker. The production of IFN-γ is associated with an improved response to immune ...

We have worked extensively on signal transduction crosstalk between cytokines that activate the Jak-STAT signaling pathway, such as IFN-g, IFN-a and IL-10, and inflammatory activators of macrophages ...

Design Experimental colitis was induced in mice deficient in components of the IL-20 and signal transducer and activator of transcription (STAT)2 signalling pathways ... Conclusion IL-20 controls ...

Nigel, who is based in the Trinity Biomedical Sciences Institute (TBSI), said: "Interferon-alpha, which activates signals in our cells through the JAK/STAT pathway, is responsible for kick ...