Interferon gamma (IFN-γ) is a cytokine that induces ... actions of the cells are activated when IFN-γ binds to the IFN-γ receptor, which is made up of IFNGR1 and IFNGR2. IFN-γ expression ...

BCG specific T cell immunity is not sufficient for tumor control. Further, BCG augments the effector functions of tumor specific T cells, which signal through the IFN-gamma receptor on tumor cells.

The team also generated a mouse strain with a conditional deletion of IFN-gamma receptor on muscle cells. The exercise capacity of these mice improved much more after training than that of control ...

A new study in Nature identifies a long-sought cytoplasmic 'sensor' that is responsible, at least in part, for interferon responses induced by double-stranded DNA. How do cells detect non-self ...

In a healthy individual, T cells find cancer cells and release the protein interferon-gamma, a potent cytokine that stops tumor growth. However, interferon-gamma has limited effects on directly ...